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KMID : 0352720090330010001
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Journal of Ginseng Research
2009 Volume.33 No. 1 p.1 ~ p.7
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Anti-oxidative properties of ginseng
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Kim Eun-Hye
Rhee Dong-Kwon
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Abstract
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Clinical and animal studies have shown that free radical overload is an important cause for a variety of diseases.
Although ginseng has been recognized as antioxidant, how it modulates anti-oxidative process at the molecular
level remains unknown. Free radical production is induced by tumor necrosis factor-α (TNF-α) under the stress condition,
and TNF-α release is activated by TNF-α-converting enzyme (TACE). Since TACE inhibitor is also well known for antiinflammatory agent, ginseng seems to show anti-oxidative activity by repressing TACE pathway. Further studies on signal transduction would be warranted to elucidate molecular action mechanisms of ginseng on anti-oxidation and anti-inflammation.
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KEYWORD
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Korean ginseng, anti-oxidant, TNF-α, TNF-α-converting enzyme
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